Oncologic and obstetric outcomes of fertility-sparing surgery for borderline ovarian tumors in women of reproductive age: a retrospective cohort study
Research Square (Research Square)(2020)
摘要
Objective
To retrospectively evaluate the oncologic and obstetric outcomes of fertility-sparing surgery (FSS) for borderline ovarian tumors(BOT).
Methods
132 patients with borderline ovarian tumors were divided into the incompletely staging surgery (ISS) group and the completely staging surgery (CSS) group. The overall survival and disease-free survival curves were determined using the Kaplan–Meier method. The Cox proportional hazards method was used to assess the association between the variables and live birth and multivariate analysis to identify the independent associations.
Results
Chi-square and Kaplan-Meier analyses showed no significant differences in overall survival between the two groups (p = 1.000 and p = 0.716, respectively). The CSS group had fewer relapses and longer disease-free survival than ISS (p = 0.003). There was no statistical difference in live birth rate between two groups (crude odds ratio = 0.885, 95%CI 0.411–1.903, p = 0.755; adjusted odds ratio = 0.848, 95%CI 0.366–1.963, p = 0.700). Age was the only independent risk factor for live birth (adjusted odds ratio = 0.902, 95%CI 0.823–0.988, p = 0.027). Mean live birth intervals after FSS was 31.86 ± 19.325 months.
Conclusions
CSS significantly increased the disease-free survival time of BOT and reduced the relapse risk. However, CSS had a slightly negative and statistically insignificant association with live birth.
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关键词
ovarian tumors,obstetric outcomes,reproductive age,fertility-sparing
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