mTORC 1-induced retinal progenitor cell overproliferation leads to 1 accelerated mitotic aging and degeneration of descendent Müller glia 2 3

1 mTORC1-induced retinal progenitor cell overproliferation leads to 1 accelerated mitotic aging and degeneration of descendent Müller glia 2 3 Soyeon Lim, You-Joung Kim, Sooyeon Park, Ji-Heon Choi, Younghoon Sung, Katsuhiko 4 Nishimori, Zbynek Kozmik, Han-Woong Lee, and Jin Woo Kim 5 6 1 Department of Biological Sciences, Korea Advanced Institute of Science and Technology 7 (KAIST), Daejeon, Korea 8 2 Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, 9 Seoul, Korea 10 3 Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, 11 Korea 12 4 Department of Obesity and Internal Inflammation, Fukushima Medical University, Fukushima, 13 Japan 14 5 Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic 15 6 Correspondence and Lead Contact: jinwookim@kaist.ac.kr 16