Growth hormone secretagogue peptide A233 upregulates Mx expression in teleost fish in vitro and in vivo
Archives of Virology(2022)
摘要
Aquaculture constitutes an alternative source for food production and contributes to a reduction in the indiscriminate catching of aquatic organisms in their natural environment. However, high mortality during the larval state remains a challenge in this sector, mainly because of factors such as diet and diseases caused by pathogens. Therefore, growth and health management is a key strategy for sustainable aquaculture. Synthetic growth hormone secretagogues (GHSs) are a family of ligands that can stimulate pituitary growth hormone release as well as the function of ghrelin, contributing to the immune responses in a variety of vertebrates, including fish. The A233 decapeptide is a GHS with a demonstrated impact on growth, immune system function, and antioxidant defense in tilapia fish, but no antiviral activity has been described for this peptide. Here, using an in vitro model (TRG-2 cells) and two in vivo models (sea bream [ Sparus aurata ]) and zebrafish [ Danio rerio ]), we demonstrate for the first time the potential antiviral effect of A233 in teleost fish.
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关键词
teleost fish,peptide,hormone,growth
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