Sequential allogeneic transplantation and ruxolitinib maintenance for a synchronous PCM1-JAK2 positive myeloid sarcoma and acute B-lymphoblastic leukemia

Giuliana Rizzuto,Matteo Leoncin,Silvia Imbergamo,Daniela Taurino, Maria Caterina Mico,Manuela Tosi,Anna Michelato,Ksenija Buklijas,Orietta Spinelli,Federico Lussana,Federica Lessi,Marco Pizzi,Laura Bonaldi,Gianni Binotto,Alessandro Rambaldi,Carmela Gurrieri

CLINICAL CASE REPORTS（2022）

引用 6|浏览4

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摘要

The translocation t(8;9)(p22;p24) results in the production of a chimeric PCM1-JAK2 fusion protein leading to the constitutive activation of the Janus Kinase 2 that renders this disease potentially sensitive to ruxolitinib. Here, we report an interesting case of PCM1-JAK2 myeloproliferative neoplasm evolving in myeloid sarcoma and B precursor ALL.

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关键词

acute B-lymphoblastic leukemia, case report, myeloid sarcoma, PCM1-JAK2 myeloproliferative neoplasm, ruxolitinib

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