A nomogram established by inflammatory markers predicting overall survival after radical resection of gastric cancer

Background The prognostic value of inflammatory markers have been confirmed in some tumors, this research was to explore more clinical markers and then build a reliable nomogram to predict overall survival after radical resection of gastric cancer.Methods 904 patients who underwent surgery at the First Affiliated Hospital of Anhui Medical University from January 2010 to January 2013 were included. Univariate and multivariate analyses were used to screen for prognostic risk factors. The construction of the nomogram is based on the Cox proportional hazard regression model. The construction of the new scoring model is analyzed by the receiver operator characteristic (ROC) curve and then compared with other clinical indicators.Results Multivariate analysis showed that TNM stage, CEA, the systemic immune-inflammation index (SII) and age were independent prognostic factors. The value of SII was better than other inflammatory markers. The new nomogram had a higher AUC value than TNM and other risk factors, and the C-index of the nomogram was highly consistent for evaluating survival of gastric cancer patients in the validation groups and training group.Conclusions Based on the serum markers and other clinical indicators, we developed a precise nomogram to predict the prognosis of gastric cancer patients after radical surgery. This new score system can provide effective help for surgeons and patients.