T cell and antibody functional correlates of severe COVID-19 3 4

TITLE PAGE 1 2 T cell and antibody functional correlates of severe COVID-19 3 4 Krystle K.Q. Yu, Stephanie Fischinger, Malisa T. Smith, Caroline Atyeo, Deniz Cizmeci, 5 Caitlin R. Wolf, Erik D. Layton, Jennifer K. Logue, Melissa S. Aguilar, Kiel Shuey, Carolin Loos, 6 Jingyou Yu, Nicholas Franko, Robert Y. Choi, Anna Wald, Dan H. Barouch, David M. 7 Koelle, Douglas Lauffenburger, Helen Y. Chu, Galit Alter*, Chetan Seshadri* 8 9 1. Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA 10 2. Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA 11 3. PhD program in Immunology and Virology, University of Duisburg-Essen, Essen, Germany 12 4. PhD program in Virology, Division of Medical Sciences, Harvard University, Boston, MA, USA 13 5. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA 14 6. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical 15 School, Boston, MA 02215, USA 16 7. Providence Medical Group, Everett, WA, USA 17 8. Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA 18 9. Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, 19 Seattle, WA, USA 20 10. Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 21 USA 22 11. Department of Global Health, University of Washington, Seattle, WA, USA 23 12. Benaroya Research Institute, Seattle, WA, USA 24 25 * These authors contributed equally 26 27 Corresponding author 28 Chetan Seshadri, M.D. 29 University of Washington School of Medicine 30 750 Republican Street, Suite E663 31 Seattle, WA 98109 32 Email: seshadri@u.washington.edu 33 Phone: 206-543-6709; Fax: 206-616-4898 34 35 . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review) preprint The copyright holder for this this version posted November 30, 2020. ; https://doi.org/10.1101/2020.11.25.20235150 doi: medRxiv preprint