Enteric glial cells mediate gut immunity and repair

Antonia Wallrapp,Daping Yang,Isaac M. Chiu

Trends in Neurosciences（2022）

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摘要

In the gut, coordinated cell interactions regulate tissue repair and immunity. How enteric glial cells (EGCs) mediate these processes remained elusive. In a recent paper, Progatzky et al. demonstrate that EGCs interact with immune and mesothelial cells under homeostasis and helminth infection, revealing an indispensable role of an interferon-γ (IFNγ)-EGC-CXCL10 axis in tissue repair.

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关键词

tissue repair,immune homeostasis,enteric glial cells,IFNγ,CXCL10,helminth infection

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