High affinity monoclonal antibody targeting Siglec-15 for cancer immunotherapy.

Fei He,Na Wang, Jiangwei Li,Luanying He,Zhao Yang,Jiandong Lu,Guoliang Xiong,Changyuan Yu,Shihui Wang

Journal of clinical and translational research（2021）

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摘要

The anti-Siglec-15 mAb prepared in this study is useful as an immune checkpoint inhibitor against Siglec-15 for normalization cancer immunotherapy. This immunotherapy provides an alternative treatment for cancer patients who are refractory to the well-known PD-L1/PD-1-targeting therapies.

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关键词

Siglec-15,cancer immunotherapy,fluorescent-activated cell sorting,hybridoma cell,monoclonal antibody

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