NMR spectroscopy of a single mammalian early stage embryo

Giulia Sivelli,Gaurasundar M Conley,Carolina Herrera,Kathryn Marable,Kyle J Rodriguez,Heinrich Bollwein,Mateus J Sudano,Jürgen Brugger,Andre J Simpson,Giovanni Boero,Marco Grisi

Journal of Magnetic Resonance（2022）

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摘要

•First data from single early stage mammalian embryos having diameters of 130–190 μm.•CMOS-based microNMR device adapted for early stage embryos and 3D cell cultures.•Detection of lipids and observation of variation of spectra from sample to sample.

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关键词

CMOS,NMR,Nanoliter,Embryo,Single cell,Lipids,Metabolism

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