Early versus the traditional start of oral intake following esophagectomy for esophageal cancer: a systematic review and meta-analysis

Background Nil by mouth is considered the standard of care during the first days following esophagectomy. However, with the routine implementation of enhanced recovery after surgery, early oral intake is more likely to be the preferred mode of nutrition following esophagectomy. The present study aims to evaluate the safety and effectiveness of early oral intake following esophagectomy for esophageal cancer. Methods Comprehensive literature searches were conducted using PubMed, Web of Science, Embase, and Cochrane Library. Weighted mean differences (WMD) and odds ratios (OR) with 95% confidence intervals (CI) were calculated as the effect sizes for continuous and dichotomous variables, respectively. Results Fourteen studies with a total of 1947 patients were included. Length of hospital stay (WMD = − 3.94, CI: − 4.98 to − 2.90; P < 0.001), the time to first flatus (WMD = − 1.13, CI: − 1.25 to − 1.01; P < 0.001) and defecation (WMD = − 1.26, CI: − 1.82 to − 0.71; P < 0.001) favored the early oral intake group. There was no statistically significant difference in mortality (OR = 1.23, CI: 0.45 to 3.36; P = 0.69). Early oral intake also did not increase the risk of pneumonia and overall postoperative complications. Conclusions Current evidence indicates early oral intake following esophagectomy seems to be safe and effective. It may be the preferred mode of nutrition following esophagectomy. However, more high-quality studies are still needed to further validate this conclusion.