Cell competition: Clonal competition protects against early tumorigenesis

Joshua D'Ambrogio, Liam Hill,Catherine Hogan

CURRENT BIOLOGY（2022）

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摘要

Aging tissues accumulate somatic mutations, yet cancer occurrence is relatively rare. A new study provides compelling evidence for why this may be the case and reveals that competition between mutant clones in oesophageal tissues protects against early tumorigenesis.

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