Development of population pharmacokinetics model of isoniazid in Indonesian patients with tuberculosis

Soedarsono Soedarsono,Rannissa Puspita Jayanti,Ni Made Mertaniasih,Tutik Kusmiati,Ariani Permatasari,Dwi Wahyu Indrawanto,Anita Nur Charisma,Rika Yuliwulandari,Nguyen Phuoc Long,Young-Kyung Choi,Pham Quang Hoa,Pham Vinh Hoa,Yong-Soon Cho,Jae-Gook Shin

International Journal of Infectious Diseases（2022）

引用 12|浏览3

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摘要

•This study reports the first population pharmacokinetics (PK) model for isoniazid (INH) in Indonesian patients with tuberculosis (TB).•The PK of INH in this population is significantly different from other populations.•N-acetyltransferase 2 (NAT2) acetylator was reconfirmed as significant covariate of variability in INH PK.

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关键词

Tuberculosis,Isoniazid,Indonesia,Population Pharmacokinetics,Therapeutic Drug Monitoring

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