Guide RNA acrobatics: the one-for-two shuffle
GENES & DEVELOPMENT(2022)
摘要
RNA modifications are crucial for the proper function of the RNAs. The sites of pseudouridines are often specified by dual hairpin guide RNAs, with one or both hairpins identifying a target uridine. In this issue of Genes & Development, Jady and colleagues (pp. 70-83) identify a novel mechanism by which a single guide RNA hairpin can specify two uridines adjacent to each other or separated by 1 nt; i.e., one for two or guide RNA acrobatics.
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关键词
pseudouridine, guide RNA acrobatics, box H/ACA RNAs, RNA-guided RNA modification, pseudouridylation, RNA-RNA interaction
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