Anti-interferon- Antibody-seropositive Disseminated Nontuberculous Mycobacterial Infection Mimicking POEMS and TAFRO Syndromes
INTERNAL MEDICINE(2022)
摘要
Disseminated nontuberculous mycobacterial infection (DNTM) is typically observed in immunocom-promised hosts. Recently, it has been reported that healthy individuals with serum neutralizing autoantibodies for interferon (IFN)-gamma can also develop DNTM. We herein report a case of anti-IFN-gamma antibody-seropositive DNTM caused by Mycobacterium kansasii with symptoms mimicking TAFRO or POEMS syndrome, includ-ing anasarca, organomegaly, skin pigmentation, polyneuropathy, osteosclerotic change, thrombocytopenia, se-rum M protein, high C-reactive protein level, and reticulin fibrosis. The combination of antimicrobial chemo-therapy with glucocorticoid and intravenous immunoglobulin improved his symptoms. Glucocorticoids may be an effective method of suppressing the production of anti-IFN-gamma antibodies in DNTM.
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关键词
disseminated nontuberculous mycobacterial infection,anti-interferon-gamma antibody,Mycobacterium kansasii,TAFRO syndrome,POEMS syndrome
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