Cyclic poly(-amino ester)s with enhanced gene transfection activity synthesized through intra-molecular cyclization

Topological structure plays a critical role in gene delivery of cationic polymers. Cyclic poly(beta-amino ester)s (CPAEs) are successfully synthesized via sequential Michael addition and free radical initiating ring-closure reaction. The CPAEs exhibit superior gene transfection efficiency and safety profile compared to their linear counterparts.