Water extract of Cayratia albifolia C.L.Li root relieves zymosan A-induced inflammation by restraining M1 macrophage polarization

Wei Li,Li Luo,Junyu Zhu,Huan Yan,Xue Yang,Wanqi Tang,Dandan Li,Dongmei He,Jin Wang,Weihong Dai,Xiaoyuan Ma,Shengxiang Ao,Wei Ma, Nana Du,Chengyi Mao, Xiaoyan Diao,Xia Yang,Daoyan Liu,Zaiqi Zhang,Huaping Liang,Fangjie Wang

Phytomedicine（2022）

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摘要

•Provide in vivo evidence for CAC in reliving zymA induced inflammation.•Reveal that CAC remits inflammation by restraining M1 macrophages polarization.•Elucidate CAC limits NF-κB, mitochondrial and mTORC1 activation in macrophages.•Demonstrate all the chemical components consisted in CAC water extract.•Identify 4-guanidinobutyric acid and kynurenic acid as the potentially active constituents.

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关键词

Cayratia albifolia C.L.Li,Inflammation,Macrophages polarization

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