Intra-host SARS-CoV-2 single-nucleotide variants emerged during the early stage of COVID-19 pandemic forecast population fixing mutations.

Yi Zhang,Ning Jiang,Weiqiang Qi,Tao Li,Yumeng Zhang,Haocheng Zhang,Jing Wu,Zhaoqin Zhu,Jingwen Ai,Chao Qiu,Wenhong Zhang

The Journal of infection（2022）

引用 3|浏览23

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摘要

•A large proportion of iSNVs could be found in the several dominant VOCs in early-stage samples.•iSNVs located spike protein may help in immune escape forecasting.•The dominant C-U/G-A in iSNVs indicate APOBEC driven SARS-CoV-2 to adaptation.

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