The Interplay between Host Defense, Infection, and Clinical Status in Septic Patients: A Narrative Review

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES(2022)

引用 6|浏览5
暂无评分
摘要
Sepsis is a life-threatening condition that arises when the body's response to an infection injures its own tissues and organs. Despite significant morbidity and mortality throughout the world, its pathogenesis and mechanisms are not clearly understood. In this narrative review, we aimed to summarize the recent developments in our understanding of the hallmarks of sepsis pathogenesis (immune and adaptive immune response, the complement system, the endothelial disfunction, and autophagy) and highlight novel laboratory diagnostic approaches. Clinical management is also discussed with pivotal consideration for antimicrobic therapy management in particular settings, such as intensive care unit, altered renal function, obesity, and burn patients.
更多
查看译文
关键词
sepsis, pathogenesis, management, diagnosis, antibiotic therapy
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要