Discovery of Phosphotyrosine-Binding Oligopeptides with Supramolecular Target Selectivity

Ana S. Pina,Leonor Morgado,Krystyna L. Duncan,Sara Carvalho,Henrique F. Carvalho,Armenio J. M. Barbosa, Beatriz de P. Mariz,Ines P. Moreira,Daniela Kalafatovic,Bruno M. Morais Faustino,Vishal Narang,Tong Wang,Charalampos G. Pappas,Isabel Ferreira,A. Cecilia A. Roque,Rein Ulijn

Chemical science（2022）

引用 5|浏览29

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摘要

Phage-display screening on self-assembled tyrosine-phosphate ligands enables the identification of oligopeptides selective to dynamic supramolecular targets, with the lead peptide showing a preferred hairpin-like conformation and catalytic activity.

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