Imaging neurovascular, endothelial and structural integrity in preparation to treat small vessel diseases. The INVESTIGATE-SVDs study protocol. Part of the SVDs@Target project

•Sporadic and genetic small vessel diseases share clinical and radiological features.•Cerebrovascular dysfunctions are present in both conditions and may overlap.•INVESTIGATE-SVDs will use a multi-modal, multi-site advanced MRI protocol.•We will test associations of cerebrovascular dysfuntions and SVD phenotypes.•We will test feasibility of multi-site MRI to provide outcome measures in trials.