Plasma biomarkers reflecting high oxidative stress in the prediction of myocardial injury due to anthracycline chemotherapy and the effect of carvedilol: insights from the CECCY Trial.

Mauro Rogério de Barros Wanderley,Mônica Samuel Ávila,Miguel Morita Fernandes-Silva,Fátima das Dores Cruz,Sara Michelly Gonçalves Brandão,Vagner Oliveira Carvalho Rigaud,Ludhmila Abrahão Hajjar,Roberto Kalil Filho,Edécio Cunha-Neto,Edimar Alcides Bocchi,Silvia Moreira Ayub-Ferreira

Oncotarget（2022）

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摘要

In this subanalysis of the CECCY trial, MPO and Gal-3 biomarkers did not predict the development of CTX. However, MPO blood levels above median was associated with more severe myocardial injury and identified women who were most likely to benefit from carvedilol for primary prevention (NCT01724450).

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关键词

anthracyclines,biomarkers,cardiotoxicity,galectin-3,myeloperoxidase

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