Impaired delay discounting and time sensitivity in methcathinone use disorder
European archives of psychiatry and clinical neuroscience(2022)
摘要
Substance use disorder (SUD) is characterized by continued drug use despite adverse consequences. Methcathinone is a new type of psychoactive substance that is associated with high excitement and impulsive behaviors. However, it is unclear if individuals with methcathinone use disorders (MCUD) are with impaired decision-making ability. We analyzed the task performance in 45 male MCUD subjects and 35 male matched healthy controls (HC) with intertemporal decision-making task. Constant sensitivity discounting model was used to estimate potential changes in both discounting rate and time sensitivity. The results showed that MCUD individuals exhibited a higher delay discounting rate ( p = 0.003, Cohen’s d = 0.683) and reduced sensitivity to time ( p < 0.001, Cohen’s d = 1.662). The delay discounting rate was correlated to the first age for drug use ( r = − 0.41, p = 0.004), and the time sensitivity was negatively correlated with the duration of abstinence ( r = − 0.31, p = 0.036). We conclude that MCUD individuals are with impaired decision-making ability and time perception disturbances.
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关键词
Addiction,Constant sensitivity modeling,Intertemporal decision-making,Methcathinone
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