Acute but Not Chronic Central Administration of the Neuropeptide 26RFa (QRFP) Improves Glucose Homeostasis in Obese/Diabetic Mice.

Marie-Anne Le Solliec,Arnaud Arabo,Saloua Takhlidjt,Julie Maucotel,Mélodie Devère, Julien Riancho,Hind Berrahmoune,Jean-Luc do Rego,Jean-Claude do Rego,Alexandre Bénani,Emmanuelle Nedelec,Benjamin Lefranc,Jérôme Leprince,Youssef Anouar,Marie Picot,Nicolas Chartrel,Gaëtan Prévost

Neuroendocrinology（2022）

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摘要

Our data indicate that the central beneficial effect of 26RFa on glucose homeostasis, by potentiating GSIS, is preserved in HF mice. However, chronic administration of the neuropeptide is unable to balance glycemia in these pathophysiological conditions, suggesting that the hypothalamic 26RFa/GPR103 neuropeptidergic system mainly affects short-term regulation of glucose metabolism.

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关键词

Brain,Diabetes,Glucose homeostasis,Insulin,Obesity

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