Genome-wide scan of Alzheimer disease cohort identifies genetic loci associated with human brain metabolite levels.

Ciyang Wang,Fabiana H G Farias,Brenna C Novotny,Chengran Yang,Fengxian Wang,Victoria Fernandez,Oscar Harari,Carlos Cruchaga

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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摘要

The first brain metabolome-wide association study discovered the importance of genetic influence on brain metabolite levels. Following expectation, brain metabQTLs can be replicated in the CSF study, implicating that brain and CSF share genetic features in modulating metabolism.

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