A role for epigenetic mechanisms in Lewy body dementias.

Jennifer L Imm,Joshua Harvey,Ehsan Pishva,Byron Creese,Leonidas Chouliaras,Emma Dempster,Clive Ballard,John T O'Brien,Dag Aarsland,Jonathan Mill,Katie Lunnon

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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摘要

We are collating a well powered study cohort to interrogate the epigenetic basis of neuropathological progression and clinical staging of LB disease, controlling for levels of concomitant AD pathology. Follow up FACS sorting and analysis will allow for the cell specific methylation changes occurring in each of the LB diseases.

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