Neurobiological role of Alzheimer's disease genetic risk factor ApoE on early synaptic changes in Alzheimer-like models.

Sabine C Konings,Emma Mc Nyberg,Isak Martinsson,Gunnar K Gouras

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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摘要

ApoE appears to localize at synapses and endosomes, sites associated with early cellular changes in AD, and seems to play a role in neuronal excitability. Determining the neurobiology of ApoE, in particular in connection with cellular sites vulnerable to early changes in AD, can contribute to a better understanding of the role of ApoE in AD.

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