Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer disease among women.
Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）
摘要
We identified a novel association of AD with the interaction of sex and MGMT. Our omics analysis confirmed that epigenetically regulated expression of MGMT (involved in DNA methylation damage repair) is significantly associated with tau in women.
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