Global complement C3 lowering in adult mice protects hippocampal synaptic function.

Andre Felipe Batista,Maren K Schroeder,Khyrul Khan,Esra Yalcin,Jessy Presumey,Shaomin A Li,Michael Carroll,Cynthia A Lemere

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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摘要

Global C3 lowering in C3iKO young adult mice protected against hippocampal dysfunction many months later, suggesting that targeting C3 may be an effective therapeutic strategy for Alzheimer's disease.

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