Effects of repetitive mild traumatic brain injury on neural immune signaling and Alzheimer's disease-like pathology.

Alyssa F Pybus,Sara Bitarafan,Rowan Brothers,Erin Buckley,Levi Wood

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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摘要

Repetitive mTBI yielded amplified and sustained MAPK pathway signaling at short time points and a relationship between cytokine expression and tau phosphorylation after 1mo. These findings suggest that modulation of the MAPK pathway may be a promising therapeutic target for rmTBI.

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