Shank3 loss in AD is associated with cognitive symptoms and neuropathology.

Olivier Landry,Arnaud François,Cyntia Tremblay,Vincent Emond,Karen H Gylys,Joel N Buxbaum,Frederic Calon

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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摘要

These results in human samples and in transgenic mice are consistent with the hypothesis that Shank3 deficiency plays a role in the apparition of cognitive impairment in AD. Further work is needed to decipher the molecular mechanisms involved.

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