Proteomics profiling reveals Spp1 deficiency to downregulate UCHL1 in macrophages and to associate with lysosome-mitochondria mediated apoptotic pathways.

Altan Rentsendorj,Koen Raedschelders,Vineet Vaibhav,Rebecca A Porritt,Dieu-Trang Fuchs,Julia Sheyn,Haoshen Shi,Jargalsaikhan Dagvadorj,Yosef Koronyo,Moshe Arditi,Keith L Black,Jennifer E Van Eyk,Maya Koronyo-Hamaoui

Alzheimer's & dementia : the journal of the Alzheimer's Association（2021）

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摘要

Spp1 deficiency in macrophages downregulates UCHL1 and associates with lysosome-mitochondria mediated apoptosis pathway. This study reveals that UCHL1 is expressed by macrophages in vitro as well as in vivo in cerebral infiltrating immune cells in ADtg mice, thereby identifying novel UPS and lysosome-mitochondrial related therapeutic targets for AD.

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