Distribution of Aspergillus Species and Prevalence of Azole Resistance in Respiratory Samples From Swiss Tertiary Care Hospitals

Silvio Ragozzino,Daniel Goldenberger,Patrick R Wright,Stefan Zimmerli,Konrad Mühlethaler,Dionysios Neofytos,Arnaud Riat,Katia Boggian,Oliver Nolte,Anna Conen,Hans Fankhauser,Peter W Schreiber,Reinhard Zbinden,Frederic Lamoth,Nina Khanna

OPEN FORUM INFECTIOUS DISEASES（2022）

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摘要

Among 400 Aspergillus species from respiratory samples in Switzerland, Aspergillus fumigatus was the most frequent species. Non-fumigatus Aspergillus spp were more prevalent among solid organ transplant recipients and after azole exposure. Azole resistance was detected in 4 A fumigatus isolates, 3 of them with the "environmental" mutation TR34/L98H in the cyp51A gene.

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Aspergillus fumigatus, azole resistance, cyp51A gene, non-fumigatus Aspergillus spp, TR34, L98H mutation

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