Csp3–H monofluoroalkenylation via stereoselective C–F bond cleavage

A practical nickel- and photoredox-catalyzed Csp3–H monofluoroalkenylation through chelation-assisted Csp2–F bond cleavage of gem-difluoroalkenes for the synthesis of stereodefined tetrasubstituted fluoroalkenes has been developed. Moreover, the gem-difluoroalkenes can also undergo photoredox-catalyzed cascade twofold C–F diaminomethylation.