Biocompatible hypocrellin A-Fe(iii) nanoparticles exhibiting efficient photo-activated CDT in vitro and in vivo
DALTON TRANSACTIONS(2022)
Abstract
Chemodynamic therapy (CDT) is novel and promising for cancer treatment, however, the potential systematic toxicity of the used nanoparticles is still a big concern. In this work the biocompatible hypocrellin A-Fe(iii) nanoparticles (HA-Fe(iii) NPs) were synthesized and studied. The CDT effect of HA-Fe(iii) NPs in the dark is negligible but can be photo-activated upon red light irradiation, which is meaningful to realize precise CDT treatment by selective light irradiation. Moreover, HA-Fe(iii) NPs can also generate O-2(-), which may be converted into H2O2 to further enhance the CDT effect. As a result, HA-Fe(iii) NPs had little cytotoxicity in the dark at the concentration up to 200 mu g ml(-1), but exhibited efficient CDT activity upon red light irradiation under both normoxic and hypoxic conditions. The in vivo results also showed that HA-Fe(iii) NPs can efficiently inhibit tumor growth upon 628 nm light irradiation.
MoreTranslated text
Key words
Biomimetic Nanoparticles,Photodynamic Therapy
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined