Smokeless Tobacco Use and Prevalence of Cardiovascular Disease Among Males in the Population Assessment of Tobacco and Health (PATH) Study, Waves 1–4

•Oral smokeless tobacco (SLT) products are non-combusted forms of tobacco that can be dependence producing.•SLT use may pose health risks to users such as cardiovascular disease (CVD) through various pathways including influencing hemodynamics, endothelial dysfunction, inflammation, insulin resistance, hyperlipidemia, and arrhythmogenesis.•Past studies have suggested a small, elevated risk of CVD among SLT users compared to never tobacco users.•This study advances the literature by exploring how the duration of regular SLT use relates to CVD prevalence.•In this study of ≥ 40-year-old men only, we did not find a consistent dose–response trend for years of SLT use and prevalence of CVD.