HIF-1α inhibition attenuates severity of Achilles tendinopathy by blocking NF-κB and MAPK pathways

Xin Jiao,Yuxin Zhang,Wentao Li,Xianhao Zhou,Wenxiang Chu, Yiming Li,Zengguang Wang,Xin Sun,Chen Xu,Yaokai Gan

International Immunopharmacology（2022）

引用 5|浏览11

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摘要

•HIF-1α is highly expressed in tendinopathy.•YC-1 is an effective and potential HIF-1α inhibitor to treat tendinopathy.•HIF-1α inhibition decreases migration and proliferation of tendon cells under inflammation environment.•HIF-1α inhibition alleviates inflammation of tendon cells via NF-κB and MAPK pathways.

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关键词

Tendinopathy,HIF-1α,Migration,Proliferation,NF-κB,MAPK

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