The PER1/HIF-1alpha negative feedback loop promotes ferroptosis and inhibits tumor progression in oral squamous cell carcinoma

Yixin Yang,Hong Tang,Jiawen Zheng,Kai Yang

Translational Oncology（2022）

引用 12|浏览2

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摘要

•PER1 is negatively correlated with GPX4 and HIF-1α expression in OSCC tissue.•PER1 promotes ferroptosis in OSCC cells in a HIF-1α-dependent manner.•PER1 binds with HIF-1α to promote HIF-1α degradation.•HIF-1α binds to the PER1 promoter to inhibit PER1 transcription.

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关键词

Ferroptosis,Oral cancer,Period 1,HIF-1alpha,Clock genes

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