Two new stilbene glucosides and a new benzoic acid derivative from Tournefortia sibirica

Two new stilbene glucosides, trans-3,5-dihydroxy-4-methoxystilbene 3-O-beta-D-glucopyranoside (1), cis-3,5-dihydroxy-4-methoxystilbene 3-O-beta-D-glucopyranoside (2), one new benzoic acid derivative, cis-4-hydroxy-3-hydroxymethyl-2-butenyl benzoate 4-O-beta-D-glucopyranoside (3), and four known compounds (4 - 7) were isolated from Tournefortia sibirica L. The structures of these compounds were elucidated on the basis of spectral data. Anti-inflammatory effects of compounds (1 - 7) were evaluated in terms of inhibition on production of NO, TNF-alpha and IL-6 in LPS-induced RAW 264.7 cells. Compounds 1, 2 and 5 - 7 could inhibit the levels of NO, TNF-alpha and IL-6 in LPS-induced RAW264.7 cells with IC50 values ranging from 40.96 to 88.76 mu M.