Clinical Implications of Combination Therapy with Quizartinib and Craniospinal Irradiation for Refractory Acute Myeloid Leukemia Positive for FMS‐like Tyrosine Kinase 3‐internal Tandem Duplication with Central Nervous System Involvement

Makiko Suga,Kentaro Fukushima,Tomoaki Ueda,Yasuyuki Arai,Shunsaku Nakagawa,Yosuke Minami,Jun Toda,Akihisa Hino,Jiro Fujita,Takafumi Yokota,Naoki Hosen

Clinical case reports（2022）

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摘要

AbstractFMS‐like tyrosine kinase 3‐internal tandem duplication (FLT3‐ITD) mutation‐positive acute myeloid leukemia (AML) has a poor prognosis. We report the first case of successful bridge therapy of novel FLT3 inhibitor, quizartinib, to umbilical cord blood stem cell transplantation for FLT3‐ITD‐positive AML‐primary induction failure patients with central nervous system involvement.

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acute myeloid leukemia,CNS involvement,FLT3,inhibitor,stern cell transplantation

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