REEP6 knockout leads to defective β-adrenergic signaling in adipocytes and promotes obesity-related metabolic dysfunction.

Yeonho Son,Cheoljun Choi,Abhirup Saha,Ji-Hyun Park,Hyeonyeong Im,Yoon Keun Cho,Je Kyung Seong,Rayanne B Burl,Elizabeth A Rondini,James G Granneman,Yun-Hee Lee

Metabolism（2022）

引用 11|浏览15

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摘要

•Thermogenic stimuli upregulated REEP6 expression in adipose tissue.•REEP6 KO mice were defective in cold-induced thermogenesis and manifested an obesity-prone phenotype.•REEP6 KO impaired PKA-signaling pathway, partly through dysregulation of adenylate cyclase 3 trafficking.

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关键词

Reep6,Adcy3,Adipose tissue,PKA signaling,Obesity

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