Synthesis, in silico study (DFT, ADMET) and crystal structure of novel sulfamoyloxy-oxazolidinones: Interaction with SARS-CoV-2

•10 derivatives of novel sulfamoyloxy-oxazolidinones were designed and synthesized.•The structure of the new compounds was confirmed using spectroscopy and spectrometry methods (IR, LC-MS, NMR and EA).•Molecular docking study was performed in order to evaluate synthesized compounds as possible inhibitors of SARS-CoV-2.•The physicochemical properties of sulfamoyloxy-oxazolidinones has been optimized using bioinformatics studies (DFT, ADMET).•A single crystal of the studied compound 6C, were selected for single crystal X-ray diffraction analysis.