Deletion of Platelet CLEC-2 Decreases GPIbα-mediated Integrin Αiibβ3 Activation and Decreases Thrombosis in TTP.

Using a mouse model of thrombotic thrombocytopenic purpura (TTP), Shao and colleagues show that the deletion of platelet CLEC-2 decreases pulmonary arterial thrombosis and the severity of thrombocytopenia. They also show that an integrin αaIIbβ3 antagonist, eptifibatide, or aspirin reduces pulmonary arterial thrombosis in the TTP mice. These data indicate that platelet CLEC-2 regulates GPIbα-mediated activation of integrin αIIbβ3 in TTP and may be pharmacologically manipulated for therapeutic benefit.