Effects of Tumor Mutational Burden and Gene Alterations Associated with Radiation Response on Outcomes of Postoperative Radiation Therapy in Non-Small Cell Lung Cancer

Narek Shaverdian,Annemarie F Shepherd,Xingzhe Li,Michael Offin,Harry B Lengel,Daphna Y Gelblum,Abraham J Wu,Charles B Simone,Andreas Rimner,David R Jones,Jamie E Chaft,Nadeem Riaz,Daniel R Gomez

International Journal of Radiation Oncology*Biology*Physics（2022）

引用 7|浏览5

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摘要

The data suggest that patients with radiation-resistance gene alterations may derive minimal benefit from PORT, whereas patients with high TMB and/or alterations in DDR genes may benefit from PORT and be suited for future precision-RT strategies. Prospective studies are necessary to validate these findings.

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关键词

DNA damage repair,non-small cell lung cancer,post-operative radiation therapy,radiation resistance,tumor mutational burden

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