Isolation of CD35+ follicular dendritic cells and its role in the differentiation from B cells to IgA+GL7+ cells

Mari Hikosaka-Kuniishi,Toshiyuki Yamane,Kana Isono,Doris Narki Tetteh,Hidetoshi Yamazaki

Immunology Letters（2022）

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摘要

•FDCs were efficiently isolated by anti-CD35-Abs and magnetic bead sorting from LNs.•FDCs facilitated the differentiation of B220+ B cells to IgA+GL7+ cells.•Differentiation of IgA+GL7+ cells was enhanced by CD35+ FDCs via RARβ signaling.

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关键词

Isolation,Mesenteric lymph node,Retinoic acid,Toll-like receptor,Germinal center,Follicular dendritic cells

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