Synthetic lethal screening identifies DHODH as a target for MEN1 -mutated tumor cells

Dear Editor, Multiple endocrine neoplasia 1(MEN1)syndrome,a tumor predisposition disease caused by MEN1 germline mutation,is characterized by combined occurrence of neuroendocrine tumors(NETs)in multiple organs.1 Pancreatic neuroendocrine tumors(PanNETs)are the major cause of the increased mortality in MEN1 patients due to the most malignant potential.1,2 Treatment of NETs with MEN1 is challenging due to concomitant development of multiple tumors and the limited treatment efficiency,where first-line therapy of somatostatin analogues(SSA)shows no more than 10％objective response rate.2 Improved treatments for MEN1 NETs are urgently required.