In Vitro Anticancer Ability of Nano Fluorescent ¹¹¹In-MIL-68/PEG-FA on Hela Cells

In past decades, nanoscale metal-organic frameworks (NMOFs) have drawn more and more attention in multimodal imaging and targeting therapy of various malignant cancers. Here, we proposed to dope In-111 into fluorescent In-based NMOFs (In-MIL-68-NH2), with an attempt to prepare a new nanomedicine with great anticancer potential. As a proof of concept, the obtained NMOF (In-MIL-68/PEG-FA) with targeting motifs is able to act as a fluorescent probe to achieve Hela cell imaging. Moreover, the Auger electron emitter In-111 built in corresponding radioactive NMOF (In-111-MIL-68/PEG-FA) can bring clear damage to cancer cells, leading to a high cell killing rate of 59.3 % within 48 h. In addition, the cell cycle presented a significant dose-dependent G2/M inhibiting mode, which indicates that In-111-MIL-68/PEG-FA has the ability to facilitate the cancer cells to enter apoptotic program. This work demonstrated the potential of In-111-labelled NMOFs in specific killings of cancer cells, providing a new approach to develop nanomedicines with theranostic function.