Inhaled pulmonary vasodilators are not associated with improved gas exchange in mechanically ventilated patients with COVID-19: A retrospective cohort study

Anthony Steven Lubinsky,Shari B. Brosnahan,Andrew Lehr,Ola Elnadoury, Jacklyn Hagedorn,Bhaskara Garimella,Michael T. Bender,Nancy Amoroso,Antonio Artigas,Lieuwe D.J. Bos,David Kaufman

Journal of Critical Care（2022）

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摘要

•Inhaled pulmonary vasodilators were not associated with improvement in gas exchange in a cohort of mechanically ventilated patients with severe COVID-19. Patients receiving inhaled nitric oxide or inhaled epoprostenol were included. Gas exchange parameters studied were PaO2:FiO2, Oxygenation Index, and Ventilatory Ratio over a five day period.

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COVID-19,Inhaled nitric oxide,Epoprostenol,Ventilatory ratio,ARDS,Respiratory failure

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