Coxsackie B Virus.

Coxsackie B virus (CVB) was first isolated in the late 1940s in Coxsackie, New York, and is now known to be widespread worldwide. Infections are common and show some seasonal variation as infections are more common during the summer and early fall. The virus particle is small, nonenveloped, and contains a positive single-stranded RNA genome. The virus attaches to a cellular receptor (often the Coxsackie-adenovirus receptor, CAR) on the cell surface and is then internalized via endocytic vesicles after which the virus uncoats and the RNA genome is delivered across the endosomal membrane into the cytoplasm.