Signal Propagation Within the MCL-1/BIM Protein Complex

Philipp J Heckmeier,Jeannette Ruf,David Buhrke,Brankica G Janković,Peter Hamm

Journal of Molecular Biology（2022）

引用 3|浏览11

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摘要

•The complex formation of the protein MCL-1 and its inhibitor BIM is not understood.•An artificial photoswitchable variant of the MCL-1/BIM complex was designed.•We destabilized the complex and recorded transient IR spectra from ps to μs.•We detected a cascade of structural rearrangements of both, MCL-1 and BIM.•The revealed signal propagation helps to understand the MCL-1/BIM binding mechanism.

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关键词

protein-ligand binding mechanism,allostery,protein dynamics,photo-switching,transient infrared spectroscopy

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