Deformation-based morphometry identifies deep brain structures protected by ocrelizumab

Zhuang Song,Anithapriya Krishnan,Laura Gaetano,Nicholas J. Tustison,David Clayton,Alex de Crespigny,Thomas Bengtsson,Xiaoming Jia,Richard A.D. Carano

NeuroImage: Clinical（2022）

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摘要

•Deformation based morphometry detected ocrelizumab suppression of deep brain atrophy.•Brainstem shrinkage and ventricle expansion were linked with disability progression.•Identified deep brain structures may enable development of novel biomarkers.

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关键词

9HPT,ANTs,CDP,CSF,CNS,DBM,VBM,DMT,EDSS,IFN,ITT,LME,OCR,ROI,SST,T25FW

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